At a tiny Parisian café, the adorable yet painfully shy Amélie accidentally discovers a gift for helping others. Soon Amelie is spending her days as a matchmaker, guardian angel, and all-around do-gooder. But when she bumps into a handsome stranger, will she find the courage to become the star of her very own love story?
| Amélie Poulain | Audrey Tautou |
| Nino Quincampoix | Mathieu Kassovitz |
| Raphaël Poulain | Rufus |
| Raymond Dufayel | Serge Merlin |
| Lucien | Jamel Debbouze |
| Gina | Clotilde Mollet |
| Suzanne | Claire Maurier |
| Georgette | Isabelle Nanty |
| Joseph | Dominique Pinon |
| Hipolito | Artus de Penguern |
| Madeleine Wallace | Yolande Moreau |
| Collignon | Urbain Cancelier |
| Amandine Poulain | Lorella Cravotta |
| Dominique Bretodeau | Maurice Bénichou |
| Mr. Collignon | Michel Robin |
| Mrs. Collignon | Andrée Damant |
| Eva | Claude Perron |
| Philomène | Armelle |
| Man in Photo | Ticky Holgado |
| Narrator (voice) | André Dussollier |
| Eugène Koler | Eugène Berthier |
| Man with Pissoir | Charles-Roger Bour |
| Young Dominique | Kevin Dias |
| Young Amélie | Flora Guiet |
| Young Nino | Amaury Babault |
| Small Hands | Marion Pressburger |
| Amandine's Grocer | Luc Palun |
| Woman in Coma | Fabienne Chaudat |
| Amélie's Neighbor | Dominique Bettenfeld |
| Client Humiliating Friend | Jacques Viala |
| Humiliated Friend | Fabien Béhar |
| Humiliated Friend's Son | Jonathan Joss |
| Homeless Man | Jean-Pierre Becker |
| Blind Man | Jean Darie |
| Endive Client | Thierry Gibault |
| Endive Client's Friend | François Bercovici |
| Young Dominique | Franck Monier |
| SDF | Guillaume Viry |
| Dominique's Wife | Valérie Zarrouk |
| Concierge of the Dead | Marie-Laure Descoureaux |
| Aunt Josette | Sophie Tellier |
| Teacher | Gérald Weingand |
| Bistro Owner | François Viaur |
| Bistro Employee | Paule Daré |
| Unknown at Photo Booth | Marc Amyot |
| Tobacco Store Costumer | Myriam Labbé |
| Operated on the Nasal Septa | Jean Rupert |
| Newspaper Seller | Frankie Pain |
| Grocery Customer | Julianna Kovacs |
| Train Controller | Philippe Paimblanc |
| Twin #1 | Mady Malroux |
| Twin #2 | Monette Malroux |
| Café Customer | Robert Gendreu |
| Laughing Woman | Valériane de Villeneuve |
| Samantha | Isis Peyrade |
| Ghost Train Cashier | Raymonde Heudeline |
| Woman Near Merry-Go-Round | Christiane Bopp |
| Man Statue | Thierry Arfeuillères |
| Little Boy of Sacré-Coeur | Jerry Lucas |
| Street Blower | Patrick Paroux |
| Concierge's Postman | François Aubineau |
| Poulain's Postman | Philippe Beautier |
| Pretty Girl | Karine Asure |
| Félix L'Herbier | Régis Iacono |
| Palace Video (voice) | Franck-Olivier Bonnet |
| Concierge's Husband (voice) | Alain Floret |
| Jacques Grosjean (voice) | Jean-Pol Brissart |
| Frédéric Mitterrand (voice) | Frédéric Mitterrand |
| Montmartre Man (uncredited) | Laurent Delpit |
| Nymphomaniac (uncredited) | Manoush |
| (voice) (uncredited) | Jacques Thébault |
| (uncredited) | Dean Baykan |
| (uncredited) | Clément Chebli |
| (uncredited) | Eloïse Labro |
