Murderesses Velma Kelly and Roxie Hart find themselves on death row together and fight for the fame that will keep them from the gallows in 1920s Chicago.
| Roxie Hart | Renée Zellweger |
| Velma Kelly | Catherine Zeta-Jones |
| Billy Flynn | Richard Gere |
| Matron Mama Morton | Queen Latifah |
| Katalin Helinski "Hunyak" | Ekaterina Chtchelkanova |
| Amos Hart | John C. Reilly |
| Mary Sunshine | Christine Baranski |
| Kitty Baxter | Lucy Liu |
| Bandleader | Taye Diggs |
| Harrison | Colm Feore |
| Fred Casely | Dominic West |
| Mona | Mya |
| June | Deidre Goodwin |
| Annie | Denise Faye |
| Liz | Susan Misner |
| Stage Manager | Cliff Saunders |
| Mrs. Borusewicz | Jayne Eastwood |
| Police Photographer | Bruce Beaton |
| Sergeant Fogarty | Roman Podhora |
| Newspaper Photographer | Rob Smith |
| Reporter | Sean Wayne Doyle |
| Prison Clerk | Steve Behal |
| Prison Guard | Robbie Rox |
| Nickie | Chita Rivera |
| Bernie | Joey Pizzi |
| Ezekial Young | Scott Wise |
| Wilbur | Ken Ard |
| Hunyak's Husband | Marc Calamia |
| Veronica | Niki Wray |
| Charlie | Gregory Mitchell |
| Al Lipschitz | Sebastian La Cause |
| Billy's Assistant | Brendan Wall |
| "Gun" Reporter #1 | Cleve Asbury |
| "Gun" Reporter #2 | Rick Negron |
| "Gun" Reporter #3 | Shaun Amyot |
| Billy's Secretary | Eve Crawford |
| Newsreel Announcer | Bill Corsair |
| Auctioneer | Bill Britt |
| Sailor | Gerry Fiorini |
| Perfume Lady | Elizabeth Law |
| Harry | Joseph Scoren |
| Bare Woman #1 | Monique Ganderton |
| Bare Woman #2 | April Morgan |
| Groin Reporter | Marty Moreau |
| Doctor | Conrad Dunn |
| Bailiff | Jonathan Whittaker |
| Jury Foreman | Rod Campbell |
| Harrison's Assistant | Brett Caruso |
| Judge | Sean McCann |
| Court Clerk | Jeff Clarke |
| Newsboy | Patrick Salvagna |
| Woman Shooter | Kathryn Zenna |
| Club Owner | Jeff Pustil |
| Female Dancer | Roxane Barlow |
| Female Dancer | Jocelyn Dowling |
| Female Dancer | Melanie A. Gage |
| Female Dancer | Michelle Johnston |
| Female Dancer | Charley King |
| Female Dancer | Mary Ann Lamb |
| Female Dancer | Vicky Lambert |
| Female Dancer | Tara Nicole Hughes |
| Female Dancer | Cynthia Onrubia |
| Female Dancer | Karine Plantadit |
| Female Dancer | Jennifer Savelli |
| Female Dancer | Natalie Willes |
| Female Dancer | Karen Andrew |
| Female Dancer | Kelsey Chace |
| Female Dancer | Catherine Chiarelli |
| Female Dancer | Theresa Coombe |
| Female Dancer | Lisa Ferguson |
| Female Dancer | Melissa Flerangile |
| Female Dancer | Michelle Galati |
| Female Dancer | Sheri Godfrey |
| Female Dancer | Brittany Gray |
| Female Dancer | Karen Holness |
| Female Dancer | Amber-Kelly Mackereth |
| Female Dancer | Jodi McFadden |
| Female Dancer | Faye Rauw |
| Female Dancer | Rhonda Roberts |
| Female Dancer | Leigh Torlage |
| Female Dancer | Robyn Wong |
| Male Dancer | Ted Banfalvi |
| Male Dancer | Harrison Beal |
| Male Dancer | Paul Becker |
| Male Dancer | Jean-Luc Côté |
| Male Dancer | Scott Fowler |
| Male Dancer | Edgar Godineaux |
| Male Dancer | Bill Hartung |
| Male Dancer | Darren Lee |
| Male Dancer | Troy P. Liddell |
| Male Dancer | Blake McGrath |
| Male Dancer | Robert Montano |
| Male Dancer | Sean Palmer |
| Male Dancer | Desmond Richardson |
| Male Dancer | Martin Samuel |
| Male Dancer | Jason Sermonia |
| Male Dancer | Jeff Siebert |
| Male Dancer | Sergio Trujillo |
| Acrobat | Stacy Clark Baisley |
| Acrobat | Megan Fehlberg |
| Acrobat | Rachel Jacobs |
| Acrobat | Rebecca Leonard |
| Acrobat | Erin Michie |
| Acrobat | Danielle Rueda-Watts |
| Female Ensemble | Dana Calitri |
| Female Ensemble | Kate Coffman-Lloyd |
| Male Ensemble | Curtis King Jr. |
| Female Ensemble | Laura Dean |
| Female Ensemble | Margaret Dorn |
| Female Ensemble | Capathia Jenkins |
| Female Ensemble | Audrey Martells |
| Female Ensemble | Sara Ramirez |
| Female Ensemble | Nicki Richards |
| Male Ensemble | Dennis Collins |
| Male Ensemble | Darius De Haas |
| Male Ensemble | Willie Falk |
| Male Ensemble (uncredited) | Timothy Shew |
| Male Ensemble (uncredited) | Alfonzo Thornton |
| Male Ensemble (uncredited) | Eric Troyer |
