Henry Brogan is an elite 51-year-old assassin who's ready to call it quits after completing his 72nd job. His plans get turned upside down when he becomes the target of a mysterious operative who can seemingly predict his every move. To his horror, Brogan soon learns that the man who's trying to kill him is a younger, faster, cloned version of himself.
| Henry Brogen / Junior | Will Smith |
| Danny Zakarweski | Mary Elizabeth Winstead |
| Clay Verris | Clive Owen |
| Baron | Benedict Wong |
| Jack Willis | Douglas Hodge |
| Del Patterson | Ralph Brown |
| Janet Lassiter | Linda Emond |
| Yuri Kovacs | Ilia Volok |
| Marino | E.J. Bonilla |
| Junior (On-Set Reference) | Victor Hugo |
| Bicycle Messenger | David Shae |
| Kitty (Jack's Girlfriend) | Theodora Miranne |
| Henry's Dad | Diego Adonye |
| Henry's Mom | Lilla Banak |
| Valery Dormov | Igor Szasz |
| Young Girl on Train | Alexa GyÖrgy |
| Mother on Train | Fernanda Dorogi |
| Aniko (Lab Technician) | Alexandra Szucs |
| Key Shack Agent | Tim Connolly |
| Patterson's Son | Daniel Salyers |
| High School Girl | Jordan Sherley |
| High School Principal | Tony J. Scott |
| Man at Marina | Jeff J.J. Authors |
| Connor (uncredited) | Justin James Boykin |
| School Kid | Karis Wymbs |
| Budapestian at Sauna | Frankie Verroca |
| Hungarian Student | Balázs Veres |
| Junior's Friend | Adrian Valle Torres |
| Cop | Ashton Tatum |
| Training Officer | Ferenc Iván Szabó |
| College Student | Dillon John Swanson |
| Flemish Train Announcer | Saskia Slaaf |
| Scuba Killer #1 | Kenny Sheard |
| Budapest Bathhouse Patron | Carl Salonen |
| College Student | Brianna Robinson |
| Barista #1 | Hannah Pniewski |
| Tourist | Thanh-Huy Phan |
| College Kid | Zach Mellado |
| College Student | Samantha Kudler |
| College Student | Frankie Justin |
| Student | Douglas Rizzo Johnson |
| Pedestrian | Dawit Gulilat |
| College Student | Samantha Goldman |
| DIA Agent | Chris Goad |
| Training Officer | Björn Freiberg |
| John | Christopher T. Elliott |
| Agent Demeter | Marc Demeter |
| College student | William Caraballo |
| Coffee House Hipster | Olivia Bailey |
| Barista #2 | Daniel Annone |
| College Student | Christon Andell |
