Twenty-five years after a streak of brutal murders shocked the quiet town of Woodsboro, a new killer has donned the Ghostface mask and begins targeting a group of teenagers to resurrect secrets from the town’s deadly past.
| Sam Carpenter | Melissa Barrera |
| Tara Carpenter | Jenna Ortega |
| Chad Meeks-Martin | Mason Gooding |
| Mindy Meeks-Martin | Jasmin Savoy Brown |
| Richie Kirsch | Jack Quaid |
| Amber Freeman | Mikey Madison |
| Gale Weathers | Courteney Cox |
| Dewey Riley | David Arquette |
| Sidney Prescott | Neve Campbell |
| Wes Hicks | Dylan Minnette |
| Billy Loomis | Skeet Ulrich |
| Liv McKenzie | Sonia Ammar |
| 'The Voice' (voice) | Roger L. Jackson |
| Vince Schneider | Kyle Gallner |
| Sheriff Judy Hicks | Marley Shelton |
| Deputy Farney | Reggie Conquest |
| Martha Meeks | Heather Matarazzo |
| Deputy Vinson | Chester Tam |
| Bartender | Brooke Barnhill |
| EMT | Stephen West-Rogers |
| Reporter | Milli M. |
| Movie Randy | Christopher Speed |
| Film Fails Host | Chelsea Rebecca |
| Film Fails Host | James A. Janisse |
| Party Guest (voice) (uncredited) | Jamie Kennedy |
| Flamethrower Ghostface / Party Guest (voice) (uncredited) | Matthew Lillard |
| Party Guest (voice) (uncredited) | Matt Bettinelli-Olpin |
| Party Guest (voice) (uncredited) | Tyler Gillett |
| Party Guest (voice) (uncredited) | Iya Labunka |
| Party Guest (voice) (uncredited) | Kevin Williamson |
| Party Guest (voice) (uncredited) | Marco Beltrami |
| Party Guest (voice) (uncredited) | Patrick Lussier |
| Party Guest (voice) (uncredited) | Julie Plec |
| Party Guest (voice) (uncredited) | Rian Johnson |
| Principal (voice) (uncredited) | Drew Barrymore |
