Paul Atreides, a brilliant and gifted young man born into a great destiny beyond his understanding, must travel to the most dangerous planet in the universe to ensure the future of his family and his people. As malevolent forces explode into conflict over the planet's exclusive supply of the most precious resource in existence-a commodity capable of unlocking humanity's greatest potential-only those who can conquer their fear will survive.
| Paul Atreides | Timothée Chalamet |
| Lady Jessica Atreides | Rebecca Ferguson |
| Duke Leto Atreides | Oscar Isaac |
| Duncan Idaho | Jason Momoa |
| Baron Vladimir Harkonnen | Stellan Skarsgård |
| Thufir Hawat | Stephen McKinley Henderson |
| Gurney Halleck | Josh Brolin |
| Stilgar | Javier Bardem |
| Dr. Liet Kynes | Sharon Duncan-Brewster |
| Dr. Wellington Yueh | Chang Chen |
| Beast Rabban Harkonnen | Dave Bautista |
| Piter de Vries | David Dastmalchian |
| Chani | Zendaya |
| Reverend Mother Mohiam | Charlotte Rampling |
| Jamis | Babs Olusanmokun |
| Herald of the Change | Benjamin Clementine |
| Bene Gesserit Sister | Souad Faress |
| Shadout Mapes | Golda Rosheuvel |
| Lieutenant Lanville | Roger Yuan |
| Arrakeen Residency Gardener | Seun Shote |
| Sardaukar Bashar | Neil Bell |
| Hawat Specialist | Oliver Ryan |
| Harkonnen Trooper | Stephen Collins |
| Harkonnen Trooper | Charlie Rawes |
| Harkonnen Trooper | Richard Carter |
| Sardaukar Assassin | Benjamin Dilloway |
| Shamir | Elmi Rashid Elmi |
| Tanat | Tachia Newall |
| Female Fremen | Gloria Obianyo |
| Male Fremen | Fehinti Balogun |
| Baron Servant | Dora Kápolnai-Schvab |
| Baron Servant | Joelle |
| Atreides Lieutenant | Jimmy Walker |
| Sardaukar Soldier | Paul Bullion |
| Human Spider Proxy | Milena Sidorova |
| Harkonnen Guard | János Timkó |
| Bene Gesserit Ancestor (voice) | Jean Gilpin |
| Bene Gesserit Ancestor (voice) | Marianne Faithfull |
| Bene Gesserit Ancestor (voice) | Ellen Dubin |
| Atreides Soldier (uncredited) | Károly Baksai |
| Leto Officer (uncredited) | Björn Freiberg |
| Sardaukar Soldier (uncredited) | Balázs Megyeri |
| Gurney Sergeant (uncredited) | Michael Nardone |
| Hawat Officer (uncredited) | Duncan Pow |
| Leto Officer (uncredited) | Ferenc Iván Szabó |
| Harkonnen Medic (uncredited) | Elemér Szatmári |
| Sardaukar Soldier (uncredited) | Peter Sztojanov, Jr. |
| Sardaukar Soldier (uncredited) | István Áldott |
