Pennsylvania, 1956. Frank Sheeran, a war veteran of Irish origin who works as a truck driver, accidentally meets mobster Russell Bufalino. Once Frank becomes his trusted man, Bufalino sends him to Chicago with the task of helping Jimmy Hoffa, a powerful union leader related to organized crime, with whom Frank will maintain a close friendship for nearly twenty years.
| Frank Sheeran | Robert De Niro |
| Jimmy Hoffa | Al Pacino |
| Russell Bufalino | Joe Pesci |
| Angelo Bruno | Harvey Keitel |
| Bill Bufalino | Ray Romano |
| Skinny Razor | Bobby Cannavale |
| Older Peggy Sheeran | Anna Paquin |
| Anthony 'Tony Pro' Provenzano | Stephen Graham |
| Irene Sheeran | Stephanie Kurtzuba |
| Robert Kennedy / RFK | Jack Huston |
| Carrie Bufalino | Kathrine Narducci |
| Chuckie O'Brien | Jesse Plemons |
| Fat Tony Salerno | Domenick Lombardozzi |
| Whispers DiTullio | Paul Herman |
| Frank 'Fitz' Fitzsimmons | Gary Basaraba |
| Older Dolores Sheeran | Marin Ireland |
| Young Peggy Sheeran | Lucy Gallina |
| Assisted Living Priest | Jonathan Morris |
| Nurse | Dascha Polanco |
| Josephine 'Jo' Hoffa | Welker White |
| Sally Bugs | Louis Cancelmi |
| Joe Glimco | Bo Dietl |
| Crazy Joe Gallo | Sebastian Maniscalco |
| Mary Sheeran | Aleksa Palladino |
| Jerry Vale | Steven Van Zandt |
| Don Rickles | Jim Norton |
| E. Howard 'Big Ears' Hunt | Daniel H. Jenkins |
| FBI Agent #1 | Billy Smith |
| John McCullough | Kevin O'Rourke |
| Casket Salesman | Action Bronson |
| Investigator | Glenn Cunningham |
| Jake Gottlieb | Paul Ben-Victor |
| Anthony 'Tony Jack' Giacalone | Patrick Gallo |
| Mother of Sorrows Priest | James Martin |
| Allen Dorfman | Jake Hoffman |
| Ewing King | Barry Primus |
| Deadbeat | Danny A. Abeckaser |
| Food Fair Manager | Anthony J. Gallo |
| Prosecutor Jim Neal | J.C. MacKenzie |
| Frank Sindone | Joseph Bono |
| Phil Testa | Jamil Antonio Stefan |
| Dave Ferrie | Louis Vanaria |
| Ed Partin | Craig Vincent |
| Joe Colombo | John Polce |
| Jimmy 'The Weasel' Fratianno | Joseph Riccobene |
| Meat Company Yard Manager | Vinny Vella |
| Warren Swanson | Thomas E. Sullivan |
| Anthony 'Tony 3 Fingers' Castellito | John Cenatiempo |
| Anastasia Bodyguard | Robert Mladinich |
| Phil The Bartender | Rich Reilly |
| Johnny - Friendly Lounge | Robert Funaro |
| Young Maryanne Sheeran | Tess Price |
| Older Maryanne Sheeran | Jennifer Mudge |
| Young Dolores | India Ennenga |
| Young Connie Sheeran | Jordyn DiNatale |
| Older Connie Sheeran | Kate Arrington |
| Teamster | Bernie Martin |
| Silver Shop Owner | Philip Suriano |
| Silver Shop Owner's Son | Tony Suriano |
| German Prisoner #1 | Jason A. Iannacone |
| German Prisoner #2 | Michael C. Brennan |
| John The Redhead | James P. Harkins |
| Sam 'Momo' Giancana | Al Linea |
| Albert Anastasia | Garry Pastore |
| Bartender - Friendly Lounge | Frank Pietrangolare |
| Friendly Lounge Guy 'Butchie' | Frank Aquilino |
| Friendly Lounge Patron | Johnny T. Sollitto |
| Peggy's Godfather | Patrick Murney |
| Peggy's Godmother | Samantha Soule |
| Judge - Frank's First Trial | Richard V. Licata |
| Villa Roma Manager | Vito Picone |
| Anastasia's Hitman #1 | Larry Mazza |
| Anastasia's Hitman #2 | Craig DiFrancia |
| Motel Manager | Ira Drukier |
| Russell's Bodyguard | Jon Bruno |
| Mobster #1 - Curtain Shop | Paul Borghese |
| Mobster #2 - Curtain Shop / Copa Guest #1 | Steven Maglio |
| Mobster #3 - Curtain Shop | James Licata |
| Curtain Shop Staff #1 | Veronica Alicino |
| Curtain Shop Staff #2 | Mike Massimino |
| Anastasia Mobster in Car #1 | James Ciccone |
| Anastasia Mobster in Car #2 | Ron Castellano |
| Grocer | Marco Greco |
| Bill Bufalino's Wife | Meghan Rafferty |
| Aldo | Aldo Sergi |
| Hoffa Rally Teamster #1 | James Lorinz |
| Hoffa Rally Teamster #2 | Jeffrey Paul |
| Hoffa Rally Teamster #3 | Robert C. Kirk |
| Bathhouse Teamster | Vince Maritato |
| Louis | Lawrence Smith |
| Barbara Hoffa | Rebecca Faulkenberry |
| James P. Hoffa | Ken Wulf Clark |
| Senator McClellan | John Rue |
| Hoffa Attorney - George Fitzgerald | Steve Routman |
| Castellito's Driver | Fernando Vera |
| Tough Teamster - Hoffa's Office | Peter Claymore |
| Phil - Milestone Hauling | Charles DelGatto |
| Cuban Worker | Michael Gongora |
| Joseph Kennedy | Eugene Bunge |
| Pro Rally Teamster #1 | Matthew F. O'Connor |
| Pro Rally Teamster #2 | Cliff Moylan |
| Pro Rally Teamster #3 | Vincenzo DelRiccio |
| Pro Rally Teamster #4 | Steve Beauchamp |
| Trucking Company Owner | Alfred Sauchelli, Jr. |
| Local 326 Truck Driver | Joe Giorgio |
| Ice Cream Shop Patron #1 | Diana Agostini |
| Ice Cream Shop Patron #2 | Lauren Aparicio |
| Ice Cream Shop Staff #1 | Kelley Rae O'Donnell |
| Ice Cream Shop Staff #2 | John Garrett Greer |
| Swanson's Booking Detective | Jack Caruso |
| Bertram B. Beveridge | John Scurti |
| Nashville Court Clerk | Thomas J. Jenkins |
| Judge William Miller | Steve Witting |
| Reporter | Luke Smith |
| Judge Frank Wilson | Brent Langdon |
| Tony Pro FBI Agent #1 | James D. Forsha |
| Tony Pro Guy #1 | Giacomino J. Matra |
| Tony Pro Guy #2 | Paul Pearlman |
| Tony Pro Guy #3 | Frank L. Messina |
| Colombo's Wife | Cilda Shaur |
| Colombo's Son #1 | Dominick LaRuffa Jr. |
| Colombo's Son #2 | Erick Zamora |
| Copa Guest #2 | Joe Caniano |
| Copa Guest #3 | Lou Martini Jr. |
| Copa Guest #4 | Michael Bottari |
| Copa Guest #5 | John Bianco |
| Gallo's Wife Sina | Margaret Anne Florence |
| Gallo's Daughter Lisa | Siena Marino |
| Gallo's Sister Carmella Fiorello | Lori Arkin |
| Pete The Greek | Nicholas Chrysan |
| Pete The Greek's Girlfriend | Samantha Coppola |
| Reporter at Prison | Logan Crawford |
| President Nixon | Jeff DeHart |
| Attorney General Mitchell | Mark Fairchild |
| Dave Johnson | Blaise Corrigan |
| Dave Johnson's Wife | Jill Brown |
| Little Fitz | Tim Neff |
| TV Host / Moderator | Matt Walton |
| NAACP President Cecil Moore | Peter Jay Fernandez |
| District Attorney Emmett Fitzpatrick | Stephen Mailer |
| Mayor Frank Rizzo | Gino Cafarelli |
| Angelo Bruno's Wife | Robin Kerbis |
| Tony Pro's Wife | Lucia Giannetta |
| Casino Photographer | Michael Romeo Ruocco |
| Golddigger Dancer | Amanda Kloots |
| Golddigger Dancer | Anne Horak |
| Golddigger Dancer | Brittany Bigelow |
| Golddigger Dancer | Vanessa Mitchell |
| Golddigger Dancer | Madison Eastman |
| Golddigger Dancer | Purdie Baumann |
| Golddigger Dancer | Jesse Wildman |
| Golddigger Dancer | Nina Lafarga |
| Jerry Vale Band | Neil Posner |
| Jerry Vale Band | Michael Leviton |
| Jerry Vale Band | Bridget Barkan |
| Jerry Vale Band | Andrea Weinzierl |
| Jerry Vale Band | Richard V. Pagano |
| Jerry Vale Band | Nicholas Wight |
| Pilot | Clark Carmichael |
| Bruno Denzetta | Joseph Russo |
| Marco Rossi | Jeremy Luke |
| Guest Dancing at Casino #1 | Barbara Eyland |
| Guest Dancing at Casino #2 | Tracy J. Everitt |
| Wedding Wise Guy #1 | Saint Marino |
| Wedding Wise Guy #2 | Mario Corry |
| Wedding Wise Guy #3 | Johnny Potenza |
| Wedding Wise Guy #4 | Joe Passaro |
| Wedding Wise Guy #5 | Patrick Borriello |
| Inmate Alfredo | Alfred Nittoli |
| Assistant US Attorney | David Aaron Baker |
| Colonoscopy Doctor | Stanley Burns |
| Prosecutor - Frank's 2nd Trial | Bill Timoney |
| Deputy Clerk - Frank's 2nd Trial | Thomas J. McDonald |
| Judge - Frank's 2nd Trial | Virl Andrick |
| Frank's Orderly | Ernest L. Sanders Jr. |
| Funeral Priest | Bill McHugh |
| FBI Agent #2 | Kevin Kane |
| Sales Girl at Crypt | Amelia Brain |
| Man in Wheelchair | Craig 'Radio Man' Castaldo |
| Bowler (uncredited) | Michael Iacono |
| Truck Driver (uncredited) | Tommy Bayiokos |
| Juror (uncredited) | Michael Cullum |
| Lewisburg Guard (uncredited) | Rick Bolander |
| Teamster (uncredited) | Shade Rupe |
| Brother in Ice Cream Parlor (uncredited) | Ian Zelbo |
| Self (archive footage)(uncredited) | Jacqueline Kennedy |
| Self (archive footage)(uncredited) | John F. Kennedy |
| Supervisor - Cadillac Linen (uncredited) | Leonard Zimmerman |
| Government Attorney (uncredited) | Norman Aaronson |
| Peggy's Classmate (uncredited) | Michael DiMonte |
| Giancana's Associate (uncredited) | Albert Gomez |
| Phil Testa (as Jamil Antonio Stefan) | Larry Romano |
| Teamster (as Bernie Martin) | John Bernard Martin |
