Dr. Victor Frankenstein, a brilliant but egotistical scientist, brings a creature to life in a monstrous experiment that ultimately leads to the undoing of both the creator and his tragic creation.
| Victor Frankenstein | Oscar Isaac |
| The Creature | Jacob Elordi |
| Harlander | Christoph Waltz |
| Elizabeth / Claire Frankenstein | Mia Goth |
| William Frankenstein | Felix Kammerer |
| Leopold Frankenstein | Charles Dance |
| Blind Man | David Bradley |
| Captain Anderson | Lars Mikkelsen |
| Young Victor Frankenstein | Christian Convery |
| Chief Officer Larsen | Nikolaj Lie Kaas |
| Young Hunter | Kyle Gatehouse |
| Hunter's Wife | Lauren Collins |
| Anna-Maria | Sofia Galasso |
| Dr. Udsen | Joachim Fjelstrup |
| Professor Krempe | Ralph Ineson |
| Professor Stokeld | Peter Millard |
| Professor Maurus | Peter MacNeill |
| Executioner | Burn Gorman |
| Old Hunter #1 | Sean Sullivan |
| Old Hunter #2 | Stuart Hughes |
| Silversmith | Gord Rand |
| Harlander's Butler | Kenton Craig |
| Outpost Clerk | Val Ovtcharov |
| Torfussen | Anders Yates |
| Prisoner #1 | Adam Brown |
| Prisoner #2 | Santiago Segura |
| Prisoner #3 | Dexter Stokes-Mellor |
| Nymph | Shian Denovan |
| Spinal Corpse | Mark Steger |
| Young William Frankenstein | Rafe Harwood |
| Head Urchin | Gregory Mann |
| Dark Angel | Roberto Campanella |
| Woman in Confessional | Rebecca Lawson-Turner |
| Professor Kugelmann | Warren Albert |
| Guest at Wedding and Bistro | Kim Morgan |
| Bistro Dancer | Chris Andrews |
| Bistro Dancer | Lewis Landini |
| Bistro Dancer | William John Banks |
| Bistro Dancer | Tess Letham |
| Bistro Dancer | Alexandros Beshonges |
| Bistro Dancer | Maria Peneva |
| Bistro Dancer | Kieran Brown |
| Bistro Dancer | Jessica Roberts Smith |
| Bistro Dancer | Rachel Elderkin |
| Bistro Dancer | Jennifer Steele |
| Bistro Dancer | Jorja Follina |
| Bistro Dancer | Malcolm Sutherland |
| Bistro Dancer | Alex Henderson |
| Bistro Dancer | Luke Watson |
| Bistro Dancer | Yasmin Hepburn |
| Bistro Dancer | Pawel Wieczorek |
| Additional Performances (puppeteer) | Frank Meschkuleit |
| Museum Bookshop Patron | Matthew Barr |
| Student (uncredited) | Luca Mehta |
