A young street-smart, Nathan Drake and his wisecracking partner Victor “Sully” Sullivan embark on a dangerous pursuit of “the greatest treasure never found” while also tracking clues that may lead to Nathan’s long-lost brother.
| Nathan Drake | Tom Holland |
| Victor 'Sully' Sullivan | Mark Wahlberg |
| Chloe Frazer | Sophia Ali |
| Jo Braddock | Tati Gabrielle |
| Santiago Moncada | Antonio Banderas |
| The Scotsman | Steven Waddington |
| Young Sam | Rudy Pankow |
| Young Nate | Tiernan Jones |
| Hugo | Pingi Moli |
| Guard at Museum | Jesús Evita |
| Sister Bernadette | Georgia Goodman |
| Police Officer | Diarmaid Murtagh |
| Carlos | Joseph Balderrama |
| Goldie | Serena Posadino |
| Zoe | Alana Boden |
| Unsuspecting Doorman | Jonathan Failla |
| Luxury Sedan Driver | Anthony Thomas |
| Auctioneer | Peter Seaton-Clark |
| Guard at Auction | Robert Maaser |
| Security Guard | Eskindir Tesfay |
| Armando Moncada | Manuel de Blas |
| Spanish Nun | Carme Capdet |
| Club Bartender #1 | Julia Schunevitsch |
| Club Bartender #2 | Alois Knapps |
| Spanish Woman in Club | Patricia Meeden |
| Hotel Guest | Nolan North |
| Hotel Bellman | Matt Barkley |
| Concepcion Helo Pilot | Jimmy Hart |
| Concepcion Co-Pilot | Brett Praed |
| Trinidad Helo PIlot | Carlo Kitzlinger |
| Gage | Pilou Asbæk |
| Young Man (uncredited) | Rubén Doblas Gundersen |
