Follow the mythic journey of Paul Atreides as he unites with Chani and the Fremen while on a path of revenge against the conspirators who destroyed his family. Facing a choice between the love of his life and the fate of the known universe, Paul endeavors to prevent a terrible future only he can foresee.
| Paul Atreides | Timothée Chalamet |
| Chani | Zendaya |
| Jessica | Rebecca Ferguson |
| Stilgar | Javier Bardem |
| Gurney Halleck | Josh Brolin |
| Feyd-Rautha | Austin Butler |
| Princess Irulan | Florence Pugh |
| Beast Rabban | Dave Bautista |
| Emperor | Christopher Walken |
| Lady Margot Fenring | Léa Seydoux |
| Baron Harkonnen | Stellan Skarsgård |
| Reverend Mother Mohiam | Charlotte Rampling |
| Shishakli | Souheila Yacoub |
| Lanville | Roger Yuan |
| Jamis | Babs Olusanmokun |
| Maker Keeper | Alison Halstead |
| Reverend Mother Ramallo | Giusi Merli |
| Bene Gesserit Sister | Kait Tenison |
| Bene Gesserit Sister | Tara Breathnach |
| Bene Gesserit Sister | Akiko Hitomi |
| Watermaster | Imola Gáspár |
| Young Fremen Patrol | Alison Adnet |
| Young Fremen Patrol | Hamza Baissa |
| Young Fremen Patrol | Hassan Najib |
| Young Fremen Patrol | Jasper Ryan-Cater |
| Young Fremen Patrol | Omar Elbooz |
| Young Fremen Patrol | Abdelkarim Hussein Seli Mohamed Hassanin |
| Fedaykin Leader | Joseph Beddelem |
| Fedaykin | Xavier Alba Royo |
| Fedaykin | Rachid Abbad |
| Fedaykin | Affif Ben Badra |
| Fedaykin | Botond Bóta |
| Fedaykin | Abdelaziz Boumane |
| Fedaykin | Abdellah Echahbi |
| Fedaykin | Zouhair Elakkari |
| Fedaykin | Noureddine Hajoujou |
| Fedaykin | Mohamed Mouraoui |
| Fedaykin | Adil Achraf Sayd |
| Fedaykin | Hamza Sayd |
| Fremen Nun | Hopi Grace |
| Fremen Nun | Havin Fathi |
| Fremen Nun | Kincsö Pethö |
| Young Nun | Cat Simmons |
| Devotee | Burt Caesar |
| Devotee | Remi Fadare |
| Huge Fighter | Amer El-Erwadi |
| Fremen Onlooker | Tedroy Newell |
| Fremen Onlooker | Oxa Hazel |
| Fremen Onlooker | Hajiyeva Pakiza |
| Oldest Elder | Leon Herbert |
| Female Elder | Sima Rostami |
| Elder | Yvonne Campbell |
| Elder | Joseph Charles |
| Elder | Vic Zander |
| Harkonnen Translator | Dylan Baldwin |
| Old Wounded Woman | Marcia Tucker |
| Wounded Fremen | Nicola Brome |
| Wounded Fremen | Kathy Owen |
| Fundamentalist Fighter | Huw Novelli |
| Fundamentalist Fighter | Moe Bar-El |
| Fundamentalist Fighter | Serhat Metin |
| Fundamentalist Fighter | Amra Mallassi |
| Fundamentalist Fighter | Adam Bloom |
| Sentinel Leader | Luis Alkmim |
| Smuggler Driver | Jordan Long |
| Wounded Smuggler | Omar A.K. |
| Arena Gladiator | Zdeněk Dvořáček |
| Arena Gladiator | Billy Clements |
| Harkonnen Commander | Anton Valensi |
| Harkonnen Commander | Lex Daniel |
| Harkonnen Commander | Dominic McHale |
| Harkonnen Commander | Paul Boyle |
| Ornithopter Military Pilot | Niall White |
| Harkonnen Scanner Operator | Tony Cook |
| Harkonnen Officer | Gábor Szemán |
| Game Supervisor | Jonathan Gunning |
| Slave Master | Will Irvine |
| Weapon Master | Alan Mehdizadeh |
| Harpy | Rex Adams |
| Harpy | Molly Mcowan |
| Harpy | Ana Cilas |
| Feyd-Rautha's Attendant | Kajsa Mohammar |
| Feyd-Rautha's Attendant | Sára Bácsfalvi |
| Feyd-Rautha's Attendant | Zsófia Kocsis |
| Spice Steward | Matthew Sim |
| Bashar | Steve Wall |
| Imperial Council | Italo Amerighi |
| Imperial Council | Tim Hilborne |
| Imperial Council | Cecile Sinclair |
| Imperial Servant | Tracy Coogan |
| Baby Jessica | Zoe Kata Kaska |
| Baron Proxy | Jimmy Walker |
| Female Fremen Fighter | Rand Faris |
| Male Fremen Fighter | Fouad Humaidan |
| Male Fremen Fighter | Manaf Irani |
| Baron Servant | Dora Kápolnai-Schvab |
| Baron Servant | Joelle |
| Alia Atreides (uncredited) | Anya Taylor-Joy |
