Following the latest Ghostface killings, the four survivors leave Woodsboro behind and start a fresh chapter.
| Sam Carpenter | Melissa Barrera |
| Tara Carpenter | Jenna Ortega |
| Mindy Meeks-Martin | Jasmin Savoy Brown |
| Chad Meeks-Martin | Mason Gooding |
| Ethan Landry | Jack Champion |
| 'The Voice' (voice) | Roger L. Jackson |
| Quinn Bailey | Liana Liberato |
| Detective Bailey | Dermot Mulroney |
| Anika Kayoko | Devyn Nekoda |
| Danny Brackett | Josh Segarra |
| Kirby Reed | Hayden Panettiere |
| Dr. Christopher Stone | Henry Czerny |
| Jason Carvey | Tony Revolori |
| Billy Loomis | Skeet Ulrich |
| Laura Crane | Samara Weaving |
| Gale Weathers | Courteney Cox |
| Paul 2.0 | Matthew Giuffrida |
| Frankie | Andre Anthony |
| Brooks | Thomas Cadrot |
| TV Reporter | Barry Morgan |
| Restaurant Hostess | Chanel Mings |
| Frat Party Girl | Erika Prevost |
| Frat Dude | Jesse Camacho |
| Angry Woman | Jenna Wheeler-Hughes |
| Police Officer | Mizinga Mwinga |
| Police Officer | Céleste Dubé |
| Police Officer | André Bédard |
| Reporter #1 | Eric Davis |
| Reporter #2 | Lydia Zadel |
| EMT | Elizabeth Neale |
| Gale's Cameraman | Justin Johnson |
| MTA Worker | Stephane Ishmael |
| Ghostface | Max Laferriere |
| Richie Kirsch (uncredited) | Jack Quaid |
| Bodega Clerk (uncredited) | Jason Cavalier |
| Greg Bruckner (uncredited) | Thom Newell |
| Paul 2.0 (voice) (uncredited) | Tim Robinson |
| Subway Ghostface (voice) (uncredited) | Akiva Schaffer |
