An odyssey through time and memory, centered on a place in New Jersey where—from wilderness, and then, later, from a home—love, loss, struggle, hope and legacy play out between couples and families over generations.
| Richard | Tom Hanks |
| Margaret | Robin Wright |
| Al | Paul Bettany |
| Rose | Kelly Reilly |
| Young Richard | Finn Guegan |
| Young Richard | Callum Macreadie |
| Young Richard | Ellis Grunsell |
| Young Richard | Teddy Russell |
| Elizabeth | Lauren McQueen |
| Young Elizabeth | Billie Gadsdon |
| Young Elizabeth | Beau Gadsdon |
| Young Elizabeth | Grace Lyra |
| Young Elizabeth | Jemima Macintyre |
| Jimmy | Harry Marcus |
| Young Jimmy | Diego Scott |
| Young Jimmy | Logan Challis |
| Young Jimmy | Albie Salter |
| Vanessa | Zsa Zsa Zemeckis |
| Young Vanessa | Eloísa Ferreira |
| Young Vanessa | Albie Mander |
| Young Vanessa | Eliza Daley |
| Young Vanessa | Elodie Crapper |
| Young Vanessa | Faith Delaney |
| Pauline Harter | Michelle Dockery |
| John Harter | Gwilym Lee |
| Violin Girl | Delilah O’Riordan |
| Leo Beekman | David Fynn |
| Stella Beekman | Ophelia Lovibond |
| Devon Harris | Nicholas Pinnock |
| Helen Harris | Nikki Amuka-Bird |
| Justin Harris | Cache Vanderpuye |
| Raquel | Anya Marco-Harris |
| Ted | Tony Way |
| Virginia | Jemima Rooper |
| Indigenous Man | Joel Oulette |
| Indigenous Woman | Dannie McCallum |
| Benjamin Franklin | Keith Bartlett |
| William Franklin | Daniel Betts |
| Elizabeth Franklin | Leslie Zemeckis |
| Billy Franklin | Alfie Todd |
| Carriage Driver | Mohammed George |
| Colonial Boy | Logan Matthews |
| Real Estate Agent 2000s | Denise Faye |
| Real Estate Agent 1940s | Jenna Boyd |
| Real Estate Agent 1900s | David Charles |
| Bethany | Lilly Aspell |
| Earl Higgins | Jonathan Aris |
| Todd | Louis Suc |
| Lisa | Eloise Webb |
| Gilbert Moore, C.H.H.P | Angus Wright |
| Businessman | Stuart Bowman |
| Revolutionary Officer | Alasdair Craig |
| Revolutionary Soldier | Martin Bassindale |
| Workman | Louis Sparks |
| Pink Bow Girl | Hope Delaney |
| Boy in Dress | Dexter Sol Ansell |
| Firefighter #1 | Phil Aizlewood |
| Firefighter #2 | Steven Dykes |
| Doctor Beven | Mitchell Mullen |
| Mourner #1 | James Eeles |
| Mourner #2 | Jack Bennett |
| Justice | Chris Rogers |
| Daughter (uncredited) | Frances Barry |
| Ghost Vanessa (uncredited) | Makenzie Carmichael |
| Richard (aged 15-16) (uncredited) | Louis Philpott |
| Observer 2 (uncredited) | Stephanie Siadatan |
| Party Guest (uncredited) | Matt Ledray |
| Party Guest (uncredited) | Giovanni Tria |
