With his wife's disappearance having become the focus of an intense media circus, a man sees the spotlight turned on him when it's suspected that he may not be innocent.
| Nick Dunne | Ben Affleck |
| Amy Dunne | Rosamund Pike |
| Desi Collings | Neil Patrick Harris |
| Tanner Bolt | Tyler Perry |
| Margo Dunne | Carrie Coon |
| Detective Rhonda Boney | Kim Dickens |
| Officer James Gilpin | Patrick Fugit |
| Rand Elliott | David Clennon |
| Marybeth Elliott | Lisa Banes |
| Ellen Abbott | Missi Pyle |
| Andie Fitzgerald | Emily Ratajkowski |
| Noelle Hawthorne | Casey Wilson |
| Greta | Lola Kirke |
| Jeff | Boyd Holbrook |
| Sharon Schieber | Sela Ward |
| Officer | Lee Norris |
| Donnelly | Jamie McShane |
| Bill Dunne | Leonard Kelly-Young |
| Shawna Kelly | Kathleen Rose Perkins |
| Walter | Pete Housman |
| Kelly Capitono | Lynn Adrianna |
| FBI | Mark Atteberry |
| Mustached Man | Darin Cooper |
| Above-It-All Journalist | Kate Campbell |
| Nervous Intern | Brett Leigh |
| Security Guard | Antonio St. James |
| Fashionista | Lauren Glazier |
| Female Officer | Julia Prud'homme |
| Doctor | Cooper Thornton |
| Earnest Girl | Casey Ruggieri |
| Maureen Dunne | Cyd Strittmatter |
| Friend 1 | Ashley Didion |
| Friend 2 | Lexis Nutt |
| Guard | L.A. Williams |
| Tweaker Teen 1 | Blake Sheldon |
| Tweaker Teen 2 | Sean Guse |
| Jason | Ricky Wood |
| Airport Traveler | Fred Cross |
| Producer | Scott Takeda |
| Lauren Nevens | Donna Rusch |
| Reporter One | Kathy Sweeney-Meadows |
| Reporter | Mark T Anderson |
| Tommy O'Hara | Scoot McNairy |
| Airport Passenger (uncredited) | Christina Alex |
| Casino Customer (uncredited) | Samuel Baca |
| Press Reporter (uncredited) | Bill Blair |
| Limo Driver (uncredited) | Thomas R. Baker |
| Needs a Fix (uncredited) | Gregoer Boru |
| Black Jack Dealer (uncredited) | Will C. |
| Waitress (uncredited) | Caroline Clements |
| Flight Attendant (uncredited) | Nancy DeMars |
| Reporter (uncredited) | Davina Joy |
| CSI Photographer (uncredited) | Michael James Kelly |
| High Roll Dealer (uncredited) | Elester Latham |
| Sharon's Assistant (uncredited) | Aaron Massey |
| Coffee Cop (uncredited) | Orion McCabe |
| Hostess (uncredited) | Roz McHenry |
| Truck Stop Cook (uncredited) | Bryan McKinley |
| Dealer (uncredited) | Teebone Mitchell |
| Amish Musician (uncredited) | Justin Nesbitt |
| Bartender (uncredited) | Mark Parrish |
| Pedestrian (uncredited) | Jaclyn Rose |
| Gate Agent (uncredited) | Sahlima |
| Bike Messenger (uncredited) | Joel Shock |
| Williamsburg Musician (uncredited) | Robert Tarpinian |
| Police Station Woman (uncredited) | Tracy Weisert |
| Makeup (uncredited) | Michelle Winters |
| Press Reporter (uncredited) | Tracy Brotherton |
| Kissing Girl (uncredited) | Matilde Matteucci |
| Librarian (uncredited) | Dale Shane |
| Camera Man (uncredited) | Kyle Hinton |
