Joe Gardner is a middle school teacher with a love for jazz music. After a successful audition at the Half Note Club, he suddenly gets into an accident that separates his soul from his body and is transported to the You Seminar, a center in which souls develop and gain passions before being transported to a newborn child. Joe must enlist help from the other souls-in-training, like 22, a soul who has spent eons in the You Seminar, in order to get back to Earth.
| Joe Gardner (voice) | Jamie Foxx |
| 22 (voice) | Tina Fey |
| Moonwind (voice) | Graham Norton |
| Terry (voice) | Rachel House |
| Counselor Jerry (voice) | Alice Braga |
| Counselor Jerry (voice) | Richard Ayoade |
| Libba Gardner (voice) | Phylicia Rashād |
| Dez (voice) | Donnell Rawlings |
| Curly (voice) | Questlove |
| Dorothea (voice) | Angela Bassett |
| Connie (voice) | Cora Champommier |
| Melba (voice) | Margo Hall |
| Paul (voice) | Daveed Diggs |
| Lulu (voice) | Rhodessa Jones |
| Counselor Jerry (voice) | Wes Studi |
| Doctor (voice) | Sakina Jaffrey |
| Counselor Jerry (voice) | Fortune Feimster |
| Hedge Fund Manager (voice) | Calum Grant |
| Therapy Cat Lady (voice) | Laura Mooney |
| Counselor Jerry (voice) | Zenobia Shroff |
| Gerel (voice) | June Squibb |
| Dancerstar (voice) | Ochuwa Oghie |
| Principal Arroyo (voice) | Jeannie Tirado |
| Dreamerwind (voice) | Cathy Cavadini |
| Dorian (voice) | Dorian Lockett |
| Basketball Announcer (voice) | Doris Burke |
| Windstar (voice) | Ronnie del Carmen |
| Miho (voice) | Esther K. Chae |
| Miali (voice) | Élisapie |
| Ray Gardner (voice) | Marcus Shelby |
| 22 "I could sound like this if I wanted to" (voice) (uncredited) | Ed Asner |
