The tale of an extraordinary family, the Madrigals, who live hidden in the mountains of Colombia, in a magical house, in a vibrant town, in a wondrous, charmed place called an Encanto. The magic of the Encanto has blessed every child in the family—every child except one, Mirabel. But when she discovers that the magic surrounding the Encanto is in danger, Mirabel decides that she, the only ordinary Madrigal, might just be her exceptional family's last hope.
| Mirabel Madrigal (voice) | Stephanie Beatriz |
| Abuela Alma Madrigal (voice) | María Cecilia Botero |
| Bruno Madrigal (voice) | John Leguizamo |
| Isabela Madrigal (voice) | Diane Guerrero |
| Luisa Madrigal (voice) | Jess Darrow |
| Pepa Madrigal (voice) | Carolina Gaitán |
| Julieta Madrigal (voice) | Angie Cepeda |
| Antonio Madrigal (voice) | Ravi Cabot-Conyers |
| Félix Madrigal (voice) | Mauro Castillo |
| Camilo Madrigal (voice) | Rhenzy Feliz |
| Agustín Madrigal (voice) | Wilmer Valderrama |
| Dolores Madrigal (voice) | Adassa |
| Mariano (voice) | Maluma |
| Señora Guzmán (voice) | Rose Portillo |
| Osvaldo (voice) | Juan Castano |
| Señora Ozma (voice) | Sarah-Nicole Robles |
| Old Arturo (voice) | Hector Elias |
| Toucan (voice) | Alan Tudyk |
| Young Mirabel / Town Kid (voice) | Noemi Josefina Flores |
| Abuela Alma Madrigal (singing voice) | Olga Merediz |
| Tiple Maestro (voice) | Jorge E. Ruiz Cano |
| Town Kid (voice) | Alyssa Bella Candiani |
| Town Kid (voice) | Paisley Day Herrera |
| Town Kid (voice) | Brooklyn Skylar Rodriguez |
| Town Kid (voice) | Ezra Rudulph |
| Parce (voice) (uncredited) | Frank Welker |
