After a shipwreck, an intelligent robot called Roz is stranded on an uninhabited island. To survive the harsh environment, Roz bonds with the island's animals and cares for an orphaned baby goose.
| Roz / Rummage (voice) | Lupita Nyong'o |
| Fink (voice) | Pedro Pascal |
| Brightbill (voice) | Kit Connor |
| Longneck (voice) | Bill Nighy |
| Vontra (voice) | Stephanie Hsu |
| Paddler (voice) | Matt Berry |
| Thunderbolt (voice) | Ving Rhames |
| Thorn (voice) | Mark Hamill |
| Pinktail (voice) | Catherine O'Hara |
| Baby Brightbill (voice) | Boone Storm |
| Snowdown (voice) | Alexandra Novelle |
| Peck (voice) | Raphael Alejandro |
| Feather (voice) | Paul-Mikél Williams |
| Honkington (voice) | Eddie Park |
| Raccoons / Squirrels / Badgers (voice) | Dee Bradley Baker |
| RECOs (voice) | Randy Thom |
| Automated Alarms (voice) | Avrielle Corti |
| Weasel 1 (voice) | Keston John |
| Weasel 2 (voice) | Max Mittelman |
| Broadfoot / Weasel 3 (voice) | Piotr Michael |
| Baby Opossum 1 (voice) | Alessandro Beghi |
| Baby Opossum 2 (voice) | Tiago Martinez |
| Baby Opossum 3 (voice) | Becca Last |
| Baby Opossum 3, 4, 5, 6 (voice) | Madelyn Turpin |
| Baby Opossum 4, 7 / Baby Bunny 2 / Baby Skunk (voice) | Kayleigh Rayne |
| Baby Opossum 8, 9 / Baby Bunny 1 (voice) | Isabelle Tupin |
| Baby Opossum 10 / Chipmunk / Baby Lynx (voice) | Beckett Blomberg |
| Baby Opossum 11 / Baby Otter (voice) | Damon Fung |
| Baby Opossum 12 (voice) | King Moore |
| Skunk (voice) | Collin Erker |
