Two youngsters from rival New York City gangs fall in love, but tensions between their respective friends build toward tragedy.
| Tony | Ansel Elgort |
| María | Rachel Zegler |
| Anita | Ariana DeBose |
| Bernardo | David Alvarez |
| Riff | Mike Faist |
| Officer Krupke | Brian d'Arcy James |
| Lieutenant Schrank | Corey Stoll |
| Valentina | Rita Moreno |
| Chino | Josh Rivera |
| Rosalía | Ana Isabelle |
| Luz | Ilda Mason |
| Anybodys | iris menas |
| Quique | Julius Anthony Rubio |
| Charita | Tanairi Sade Vazquez |
| Aníbal | David Aviles Morales |
| Braulio | Sebastian Serra |
| Chago | Ricardo Zayas |
| Flaco | Ricky Ubeda |
| Jochi | Andrei Chagas |
| Julito | Adriel Flete |
| Junior | Jacob Guzman |
| Manolo | Kelvin Delgado |
| Pipo | Carlos Sánchez Falú |
| Sebas | Yurel Echezarreta |
| Tino | David Guzman |
| Action | Sean Harrison Jones |
| A-Rab | Jess LeProtto |
| Baby John | Patrick Higgins |
| Balkan | Kyle Allen |
| Big Deal | John Michael Fiumara |
| Diesel | Kevin Csolak |
| Ice | Kyle Coffman |
| Mouthpiece | Ben Cook |
| Numbers | Harrison Coll |
| Skink | Garett Hawe |
| Snowboy | Myles Erlick |
| Tiger | Julian Elia |
| Chucho | Carlos E. Gonzalez |
| Little Moly | Daniel Patrick Russell |
| Clary | Yesenia Ayala |
| Conchi | Gabriela M. Soto |
| Cuca | Juliette Feliciano Ortiz |
| Ili | Jeanette Delgado |
| Isa | Maria Alexis Rodriguez |
| Jacinta | Edriz E. Rosa Pérez |
| Montse | Jennifer Florentino |
| Pili | Melody Martí |
| Tati | Gaby Diaz |
| Tere | Isabella Ward |
| Jet | Eloise Kropp |
| Graziella | Paloma Garcia-Lee |
| Gussie | Leigh-Ann Esty |
| Karen | Lauren Leach |
| Mack | Brittany Pollack |
| Mamie | Kellie Drobnick |
| Maxie | Skye Mattox |
| Natalie | Adriana Pierce |
| Rhonda | Jonalyn Saxer |
| Sorella | Brianna Abruzzo |
| Sweden | Halli Toland |
| Tat | Sara Esty |
| Tessa | Talia Ryder |
| Velma | Maddie Ziegler |
| Fausta | Andréa Burns |
| Glad Hand | Mike Iveson |
| Meche | Jamila Velazquez |
| Provi | Annelise Cepero |
| Lluvia | Yassmin Alers |
| Rory | Jamie Harris |
| Abe | Curtiss Cook |
| Streetwalker | Nadia Quinn |
| Puertorriqueña #1 | Arianna Rosario |
| Puertorriqueña #2 | Natalie Toro |
| Pachanga Shark Woman | María Alejandra Castillo |
| Pachanga Dancer | Mannelly Gonzalez Abreu |
| Pachanga Dancer | Maya Haghighi Guliani |
| Pachanga Dancer | Tyler Myers |
| Pachanga Dancer | Jesseudi Marcelino |
| Pachanga Dancer | German M. Castillo |
| Pachanga Dancer | Ciara Calderon |
| Pachanga Dancer | Aubrey Mills |
| Pachanga Dancer | Leonardo Ro |
| Pachanga Dancer | Adrian Castillo |
| Pachanga Dancer | Luke Joseph Fuentes Duculan |
| Pachanga Dancer | Abigail R. Valdez |
| Pachanga Dancer | Navio Lopez |
| Restaurant Owner | Victor Cruz |
| Gym Band (Band Leader) | Erik Charlston |
| Gym Band (Drums) | Clint de Ganon |
| Gym Band (Bass) | Dave Phillips |
| Gym Band (Piano) | Silvano Monasterios |
| Gym Band (Guitar) | Ric Molina |
| Gym Band (Sax) | Dan Pearson |
| Gym Band (Trombone) | Hommy Ramos |
| Gym Band (Trumpet 1) | Jose Ruiz |
| Gym Band (Trumpet 2) | Jumaane Smith |
| Gym Band (Reed Player) | Dave Noland |
| Gym Band (Percussionist 1) | Roland Morales |
| Gym Band (Percussionist 2) | Javier Diaz |
| Female Social Worker | Chryssie Whitehead |
| Custodian | Ron Stroman |
| Elderly Man | Rene Ojeda |
| Elderly Woman | Feiga Martinez |
| Cop #1 | Mike Massimino |
| Cop #2 | Ryan Woodle |
| Fabric Store Owner | David Bean |
| Gimbels Security Guard | Bert Michaels |
| Detective in Morgue | Joe Lanza |
| Young Girl María | Savannah Renée Rodriguez |
| Old Lady María | Denia Brache |
| Boxing Promoter | Lesley Bilingslea |
| Cop in Salt Shed | Andy Powers |
| Detective #2 | Reginald L. Barnes |
| Detective #3 | Patrick Noonan |
| Grizzled Trainer | Jeff Ward |
| Hardware Store Owner | Pablo Thomas |
| Taxi Passenger | Paul Niebanck |
| Demonstrator | Ixchel Cuellar |
| Demonstrator | Ricky Garcia |
| Demonstrator | Oscar Antonio Rodriguez |
| Demonstrator | José Ramón Rosario |
| Demonstrator | Doreen Montalvo |
| Construction Worker | Shade Rupe |
| Pachanga Dancer | Isaias Badilla |
| Action | Sean Harrison Jones |
| Shark (uncredited) | Jessica Marza |
