Elastigirl springs into action to save the day, while Mr. Incredible faces his greatest challenge yet – taking care of the problems of his three children.
| Bob Parr / Mr. Incredible (voice) | Craig T. Nelson |
| Helen Parr / Elastigirl (voice) | Holly Hunter |
| Violet Parr (voice) | Sarah Vowell |
| Dashiell 'Dash' Parr (voice) | Huck Milner |
| Evelyn Deavor (voice) | Catherine Keener |
| Jack-Jack Parr (voice) | Eli Fucile |
| Winston Deavor (voice) | Bob Odenkirk |
| Lucius Best / Frozone (voice) | Samuel L. Jackson |
| Tony Rydinger (voice) | Michael Bird |
| Voyd (voice) | Sophia Bush |
| Edna 'E' Mode / Additional Voices (voice) | Brad Bird |
| Krushauer / Helectrix / Additional Voices (voice) | Phil LaMarr |
| Ambassador (voice) | Isabella Rossellini |
| Chad Brentley (voice) | Adam Gates |
| Rick Dicker (voice) | Jonathan Banks |
| Underminer (voice) | John Ratzenberger |
| Screenslaver / Pizza Guy (voice) | Bill Wise |
| Monster Jack-Jack Parr (voice) | Nicholas Bird |
| Reflux / Additional Voices (voice) | Paul Eiding |
| Mayor (voice) | Barry Bostwick |
| Victor Cachet (voice) | Michael B. Johnson |
| Detective (voice) | Jere Burns |
| Detective (voice) | Adam Rodriguez |
| Honey (voice) | Kimberly Adair Clark |
| Additional Voices (voice) | Maeve Andrews |
| Additional Voices (voice) | Stephen Apostolina |
| Additional Voices (voice) | Robin Atkin Downes |
| Additional Voices (voice) | Kimberly Bailey |
| Additional Voices (voice) | Sola Bamis |
| Additional Voices (voice) | Steve Blum |
| Additional Voices (voice) | Kelly Bonbright |
| Additional Voices (voice) | Cathy Cavadini |
| Additional Voices (voice) | June Christopher |
| Additional Voices (voice) | Robert Clotworthy |
| Additional Voices (voice) | David Cowgill |
| Additional Voices (voice) | Wendy Cutler |
| Additional Voices (voice) | Rebecca Davis |
| Additional Voices (voice) | Debi Derryberry |
| Additional Voices (voice) | Bryan Dluhy |
| Additional Voices (voice) | Terri Douglas |
| Additional Voices (voice) | Greg Dykstra |
| Additional Voices (voice) | Ted Evans |
| Additional Voices (voice) | Dave Fennoy |
| Additional Voices (voice) | Jennifer Crystal Foley |
| Additional Voices (voice) | Eddie Frierson |
| Additional Voices (voice) | Grace Geller |
| Additional Voices (voice) | Jean Gilpin |
| Additional Voices (voice) | Jackie Gonneau |
| Additional Voices (voice) | Richie Gordon |
| Additional Voices (voice) | Karen Huie |
| Additional Voices (voice) | Justine Huxley |
| Additional Voices (voice) | Andrew Kishino |
| Additional Voices (voice) | Jeff Lapensee |
| Additional Voices (voice) | Patricia Lentz |
| Additional Voices (voice) | Marcella Lentz-Pope |
| Additional Voices (voice) | A.J. LoCascio |
| Additional Voices (voice) | Yuri Lowenthal |
| Additional Voices (voice) | Austin Madison |
| Additional Voices (voice) | Scott Menville |
| Additional Voices (voice) | Piotr Michael |
| Additional Voices (voice) | Melanie Minichino |
| Additional Voices (voice) | Max Mittelman |
| Additional Voices (voice) | Kitty Newton |
| Additional Voices (voice) | Teddy Newton |
| Additional Voices (voice) | Jonathan Nichols-Navarro |
| Additional Voices (voice) | Nina Ozier |
| Additional Voices (voice) | Paul Pape |
| Additional Voices (voice) | Jacqueline Pinol |
| Additional Voices (voice) | Michael Ralph |
| Additional Voices (voice) | Usher |
| Additional Voices (voice) | Lynwood Robinson |
| Additional Voices (voice) | Dennis Singletary |
| Additional Voices (voice) | Alyson Stoner |
| Additional Voices (voice) | Pepper Sweeney |
| Additional Voices (voice) | Shane Sweet |
| Additional Voices (voice) | Fred Tatasciore |
| Additional Voices (voice) | Paula Tiso |
| Additional Voices (voice) | Toya Turner |
| Additional Voices (voice) | Diamond White |
| Additional Voices (voice) | Scott Whyte |
| Additional Voices (voice) | Wally Wingert |
| Additional Voices (voice) | Matthew Wood |
| Additional Voices (voice) | Joe Zieja |
| Additional Voices (voice) | Noelle Zuber |
