During a manned mission to Mars, Astronaut Mark Watney is presumed dead after a fierce storm and left behind by his crew. But Watney has survived and finds himself stranded and alone on the hostile planet. With only meager supplies, he must draw upon his ingenuity, wit and spirit to subsist and find a way to signal to Earth that he is alive.
| Mark Watney | Matt Damon |
| Melissa Lewis | Jessica Chastain |
| Annie Montrose | Kristen Wiig |
| Theodore "Teddy" Sanders | Jeff Daniels |
| Rick Martinez | Michael Peña |
| Mitch Henderson | Sean Bean |
| Beth Johanssen | Kate Mara |
| Chris Beck | Sebastian Stan |
| Alex Vogel | Aksel Hennie |
| Vincent Kapoor | Chiwetel Ejiofor |
| Bruce Ng | Benedict Wong |
| Mindy Park | Mackenzie Davis |
| Rich Purnell | Donald Glover |
| Tim Grimes | Nick Mohammed |
| Zhu Tao | Chen Shu |
| Guo Ming | Eddy Ko Hung |
| Mike Watkins | Enzo Cilenti |
| Brendan Hatch | Jonathan Aris |
| Jack | Gruffudd Glyn |
| U.S. President | Geoffrey Thomas |
| Chinese Flight Director | Yang Haiwen |
| Wen Jiang | Narantsogt Tsogtsaikhan |
| Timer Controller | Brian Caspe |
| Launch Control | Szonja Oroszlán |
| Guidance | Mark O'Neal |
| Reporter 2 | Karen Gagnon |
| Blair | Lili Bordán |
| Reporter 1 | Nikolett Barabas |
| Police Woman | Dilyana Bouklieva |
| Nasa Staff Member | Björn Freiberg |
| Pathfinder Developer | James Fred Harkins Jr. |
| NASA Psychologist | Sam Spruell |
| Satcon | Matt Devere |
| Launcher Interface | Mike Kelly |
| Capcom | Greg De Cuir |
| Telemetry | Peter Linka |
| Comms | Declan Hannigan |
| NASA Break Room Worker | Peter Schueller |
| Vincent's Secretary | Waleska Latorre |
| CNN Reporter | Frederik Pleitgen |
| Robert Lewis | Charlie Gardner |
| Vogel's Wife | Nóra Lili Hörich |
| Marissa Martinez | Kamilla Fátyol |
| Chinese Translator | Yang Liu |
| JPL Store Man | Richard Rifkin |
| JPL White Room Worker | Nicholas Wittman |
| JPL Pathfinder Team | Ben O'Brien |
| JPL Pathfinder Team | Scott Alexander Young |
| JPL Pathfinder Team | Jason Ryan |
| JPL Pathfinder Team | James Dougherty |
| Ming's Secretary | Xue Xuxing |
| JPL White Room Worker | Balázs Medveczky |
| Receptionist | Dora Endre |
| Ryoko | Naomi Scott |
