The six-member crew of the International Space Station is tasked with studying a sample from Mars that may be the first proof of extra-terrestrial life, which proves more intelligent than ever expected.
| Dr. David Jordan | Jake Gyllenhaal |
| Rory Adams | Ryan Reynolds |
| Miranda North | Rebecca Ferguson |
| Sho Murakami | Hiroyuki Sanada |
| Ekaterina Golovkina | Olga Dihovichnaya |
| Hugh Derry | Ariyon Bakare |
| Kazumi | Naoko Mori |
| Doctor | Haruka Kuroda |
| Dominique | Camiel Warren-Taylor |
| 1st Fisherman | Alexandre Nguyen |
| 2nd Fisherman | Hiu Woong-Sin |
| 20/20 Anchor | David Muir |
| Student 1 | Allen McLean |
| Student 2 | Jesus Del Orden |
| Student 3 | Leila Grace |
| Student 4 | Mari Gvelesiani |
| 20/20 Anchor | Elizabeth Vargas |
