Superman, a journalist in Metropolis, embarks on a journey to reconcile his Kryptonian heritage with his human upbringing as Clark Kent.
| Superman | David Corenswet |
| Lois Lane | Rachel Brosnahan |
| Lex Luthor | Nicholas Hoult |
| Mr. Terrific | Edi Gathegi |
| Guy Gardner | Nathan Fillion |
| Hawkgirl | Isabela Merced |
| The Engineer | María Gabriela de Faría |
| Jimmy Olsen | Skyler Gisondo |
| Gary | Alan Tudyk |
| Superman Robot #12 (voice) | Grace Chan |
| Jor-El | Bradley Cooper |
| Lara | Angela Sarafyan |
| Superman Robot #1 (voice) | Michael Rooker |
| Superman Robot #5 (voice) | Pom Klementieff |
| Eve Teschmacher | Sara Sampaio |
| Boravian Tech | Tatiana Piper |
| Sydney Happersen | Stephen Blackehart |
| Cheryl Kimble | Giovannie Cruz |
| Ms. Jessop | Bonnie Discepolo |
| Otis Berg | Terence Rosemore |
| Amanda Marie McCoy | Natasha Halevi |
| Comms Tech | Adriana Leonard |
| Larry Chin | Paul Kim |
| Dean Farr | Jonah Lees |
| Desmond Farr | Christian Lees |
| Malik 'Mali' Ali | Dinesh Thyagarajan |
| Reggie | Rudy Quintanilla |
| Onlooker | Ryan J. Pezdirc |
| Cleavis Thornwaite | Michael Ian Black |
| Perry White | Wendell Pierce |
| Steve Lombard | Beck Bennett |
| Ma Kent | Neva Howell |
| Pa Kent | Pruitt Taylor Vince |
| Cat Grant | Mikaela Hoover |
| Ron Troupe | Christopher McDonald |
| Vasil Ghurkos | Zlatko Burić |
| Boravian General | Martin Harris |
| Rick Flag Sr. | Frank Grillo |
| General Mori | James Hiroyuki Liao |
| Flo Crawley | Tinashe Kajese |
| Albert Tyler | Luis R. Hernandez |
| Loretto Bell | Mary Chatmon |
| Young Girl | Savannah Lumar |
| Yogurt Eater | Xingu Del Rosario |
| Sphere News Reporter | Lawrence Gilligan |
| GBS Reporter | Suzanne Hobbs |
| Saved Woman | Kimmy Suzuki |
| On the Ground Reporter | Will Reeve |
| Jack Tapir | Jake Tapper |
| Construction Worker | Ira Amyx |
| International Reporter | Abel F. Alvarado |
| International Reporter | Karla Suyeon Kim |
| TV Interviewee | Jay Westbrook |
| Makeup Artist | Nea Dune |
| Heather | Darla Delgado |
| Luthorcorp Scientist | Ashleigh Morghan |
| Metamorpho | Anthony Carrigan |
| Mr. Handsome | Trevor Newlin |
| Scientist #1 | Lon Gowan |
| Scientist #2 | Taylor Valentine Lupini |
| Fleurette | Paige Mobley |
| Tech Bro | Zach Lane |
| Thug | Theo Kypri |
| Raptor Guard #1 | Michael Rosenbaum |
| Raptor Guard #2 | Alexis Prewitt |
| Raptor Guard #3 | Bobby Hernandez |
| Raptor Guard #4 | George Howard Adams |
| Raptor Sergeant #1 | David E. Collier |
| Raptor Sergeant #2 | Jimmy Chhiu |
| Sapphire Stagg | Louisa Krause |
| Young Jarhanpurian Boy | AJ Bernard |
| Jarhanpurian Kid #1 | Alayna Bernard |
| Jarhanpurian Kid #2 | Jai Soundar |
| Jarhanpurian Kid #3 | Annika Mazumdar |
| Jarhanpurian Villager #1 | Fahim Fazli |
| Jarhanpurian Villager #2 | Chaim Jeraffi |
| Woman in Car | Melissa O. Bowen |
| Boravian Commander | Torsten Kellar |
| Metropolis Citizen #1 | Johanna Braddy |
| Metropolis Citizen #2 | Austin Freeman |
| GBS Reporter #2 | Kim Brunhuber |
| Maxwell Lord | Sean Gunn |
| Metro News Reporter | Sharon Carpenter |
| Mocking Reporter | Greg Clarkson |
| TV Show Host | Milli M. |
| Armed Sergeant | Pierce Lackey |
| Young Clark (2 Years Old) | Oliver Diego Silva |
| Metropolis Citizen #3 (uncredited) | Lloyd Kaufman |
| Peacemaker (uncredited) | John Cena |
| Supergirl (uncredited) | Milly Alcock |
| Superman Robot #22 (voice) (uncredited) | Jennifer Holland |
| Typewriting Monkeys (uncredited) | James Gunn |
| Metropolis Citizen #4 (uncredited) | Eric Nally |
