Years after witnessing the death of the revered hero Maximus at the hands of his uncle, Lucius is forced to enter the Colosseum after his home is conquered by the tyrannical Emperors who now lead Rome with an iron fist. With rage in his heart and the future of the Empire at stake, Lucius must look to his past to find strength and honor to return the glory of Rome to its people.
| Lucius | Paul Mescal |
| Macrinus | Denzel Washington |
| General Acacius | Pedro Pascal |
| Lucilla | Connie Nielsen |
| Emperor Geta | Joseph Quinn |
| Emperor Caracalla | Fred Hechinger |
| Viggo | Lior Raz |
| Gracchus | Derek Jacobi |
| Jugurtha | Peter Mensah |
| Master of Ceremonies | Matt Lucas |
| Ravi | Alexander Karim |
| Arishat | Yuval Gonen |
| Quaestor | Richard McCabe |
| Senator Thraex | Tim McInnerny |
| Darius | Alec Utgoff |
| General Tegula | Rory McCann |
| Bostar | Yann Gael |
| Hyacinthia | Riana Duce |
| Young Lucius | Alfie Tempest |
| Leta | Lucilla's Servant | Amira Ghazalla |
| Boy (Numidia) | Abdelmoula Ait Sidi Lhassan |
| Boy (Numidia) | Mouaiz El Outmany |
| Boy (Numidia) | Brahim Assagour |
| Centurion (Branding) | Alexander Simkin |
| Governor (Baboon Arena) | Richard Katz |
| Master of Ceremonies (Baboon Arena) | David Ganly |
| Praetorian (Lucilla's) | Anton Saliba |
| Noble Bedouin Woman | Amal Ayouch |
| Agedilios | Hadrian Howard |
| Gladiator | Chidi Ajufo |
| Slovak | Lee Charles |
| Glyceo | Chris Hallaways |
| Phoebus | Chi Lewis-Parry |
| Gnaeus | Ángel Gómez De La Torre |
| Centurion (Lucius' Arrest) | Brahim Ait Ben Azzouz |
| Centurion (Ostia) | Maxime Rauf Ruijselaar |
| Wailing Woman | Sana El Baghdady |
| Wailing Woman | Nadia El Masnaoui |
| Wailing Woman | Nisrine Machat |
| Female Concubine | Maud Oulhen |
| Female Concubine | Estelle Courret |
| Female Concubine | Line Ancel |
| Female Concubine | Sixtine Gignoux |
| Male Concubine | Igor Badnjar |
| Male Concubine | Romi Debart |
| Male Concubine | Arnaud Préchac |
| Brennos | Tom Moutchi |
| Dorso | Dean Fagan |
| Macrinus' Companion (uncredited) | May Calamawy |
